Mythic Unique Items are among the most powerful items in the Diablo 4 DLC. They will always drop as Ancestral 800 Item Power equipment, which means they will come with at least one Greater Affix. There are currently 12 different Mythic Uniques in Diablo 4, which you can Masterworked at the Blacksmith to increase their power, however, they cannot be Tempered.

Mythic Uniques were introduced in Diablo 4 Season 5, and I believe many old players know that these Mythic Unique items are very powerful and extremely rare, even rarer than Unique items. Normally, you can only get them from all Tormented Endgame Bosses. Although the developers said that they can still drop from normal enemies in the Sanctuary, everyone knows that it is almost impossible for us to find them this way. After all, none of us have seen this happen.

So, in this guide, we’re going to share with you what I consider being the most efficient Mythic Unique farming routes to get as many Mythic Unique items as quickly as possible. Since Vessel of Hatred has so many different game modes, figuring out the best route to farm in the game can be very confusing and not at all obvious. With this guide, though, all your concerns will be put to rest. Without further ado, let’s get straight into it!

Tips To Increase Your Farming Efficiency

After some research and experimentation, we recommend a few tips you can try before you start farming that will maximize the number of Mythic Unique items you can get.

First, it’s recommended that you prioritize running the highest Torment Difficulty Level so that you can easily kill monsters quickly. Then we also recommend that you choose a build like Infinite Evade Eagle Spiritborn, which is very fast in terms of movement and can help you greatly increase your efficiency in collecting Diablo 4 Gold and other loot.

Run Helltides

Then, you can go run Helltides and go around killing monsters to collect Aberrant Cinders. In addition to killing monsters, you should also kill the Blood Maiden when she is summoned, and if you have extra Baneful Hearts on you, you should even contribute more to her summoning, as this will be tied to the rewards you can get.

The reason you need to take the time to kill the Blood Maiden is not only that she will give you Exquisite Blood, but more importantly, this can also provide Grim Favors for the Tree of Whispers. Prioritizing the completion of Whispers in the Helltides can provide players with more rewards than usual. This makes any Whispers in the Helltides a brilliant use of time.

When you have accumulated 250 Aberrant Cinders, you can open Tortured Gifts of Mysteries in each of the 2 Helltide areas. This means that each Helltide has a total of 2 Mysteries Gifts.

In addition, when you have accumulated 10 Grim Favors, you should give them to the Tree of Whispers. This way, you will get a lot of Living Steel from Mystery Chests and a lot of Malignant Hearts from Whispers.

Accumulate Boss Summoning Materials

Also, you can use Seething Opals so that you have more chances to get boss materials. Because each Seething Opal will make enemies drop different specific items more often. After opening Tortured Gifts of Mysteries, you can open other Chests to get more Living Steel. This way, you will accumulate a lot of Living Steel and Malignant Hearts, and when you have enough materials to summon Tormented Vashan and Grigoire multiple times, you can continue to kill them.

If you want, you can even find a group for these bosses so that you can rotate. However, since you can only get the summoning materials for Tormented Duriel if you summon Tormented Vashan and Grigoire, we would recommend that you fight these bosses alone, because forming a group does not increase the amount of summoning materials you get for Duriel.

Farm Tormented Duriel And Andariel In A Group

Then, once you have enough boss materials, such as Mucus-Slick Eggs from Vashan and Shards of Agony from Grigoire, you can find a group for Tormented Duriel and take turns attacking him. In this case, joining a group to fight together makes sense, because Andariel and Duriel are twice as likely to drop Mythic Unique Items compared to other Tormented Endgame Bosses, and of course, the difficulty is also doubled.

When you run out of summoning materials for Tormented Duriel, just restart farming in Helltides and repeat. If you continue to farm in this way, you will eventually get a lot of Mythic Unique items.

This is our best route and tips for farming Mythic Uniques in Diablo 4 Vessel of Hatred. Do you have a better farming method? Or do you think there are aspects of this farming method that need improvement? Of course, you can also choose to enter the IGGM discord, where there are often some giveaways and raffles. If you are lucky enough, you can easily get the Mythic Uniques you have been longing for here! Hurry up and join and be active!