Lately, I've observed a common misconception about the optimal gear farming sequence in Diablo 4 Season 3. Many players are prematurely focusing on Duriel farming.

Today, let's delve into the comprehensive strategy for acquiring BiS (Best in Slot) gear in Diablo 4 Season 3, enabling you to dominate all challenges effectively.

Step 1: Level Up All Your Glyphs To 15 (Preferably In Nightmare Vault Dungeons To Gain Construct XP Simultaneously)

Initiate your character's progression by prioritizing the advancement of all glyphs to level 15.

For optimal efficiency, undertake this task within Nightmare Vault Dungeons. These dungeons not only provide valuable construct XP but also facilitate simultaneous progression of both glyphs and constructs.

Step 2: Begin Defeating Simpler Bosses As You Approach Level 95 To Acquire The Unique Items You Require

Continue this strategy until approximately level 95, at which point you should transition to defeating bosses.

However, I'm not referring to Malphas or Duriel here. Focus on bosses like Lord Zir, Beast in the Ice, among others, which drop unique items. Consult drop tables for these bosses to identify the specific uniques required for your build. Target these bosses for farming to acquire the necessary Diablo 4 Items promptly.

Step 3: Eliminate Malphas To Acquire The Genesis Stone & Evernight Once You've Obtained Essential Unique Items

Once you've leveled your glyphs and obtained your basic unique items from the minor bosses, it's time to focus on defeating Malphas. It's crucial to tackle Malphas before Duriel.

The rationale behind this lies in the significantly higher drop rates of Genesis Stone and Evernight compared to any Uber unique from Duriel. Despite this, the relative power increase from Genesis Stone and Evernight surpasses that of any Uber from Duriel, in my opinion. Acquiring these 2 uniques grants a substantial power boost without requiring excessive time investment.

For Genesis, prioritize running Genesis, Duration Support & Tactical to benefit from Flash of Adrenaline, providing a consistent 50% damage increase with 100% uptime. Similarly, Evernight offers a permanent plus for all skills effect, akin to obtaining a Harleyquin Crest, but with a substantially higher drop rate. Therefore, beginning with Malphas is highly recommended.

Additionally, farming Malphas allows you to level up all your Tuning Stones and Governing Stones, leading to significant power gains. For instance, the resource support at level 1 provides around 10 resources per cast, while at level 10, it doubles to 20 resources per cast. This pattern of power increase applies across various Tuning Stones as they're leveled up, underscoring the importance of this endeavor.

Step 4: Commence Defeating Duriel Once You Have Secured Both Tuning Stones

However, once you've obtained Genesis and Evernight and harnessed their power, it's time to embark on the Duriel grind. If you have enough Diablo 4 Gold, you'd better equip your character in advance. This way, the process won't be so difficult.

This is when you should focus on farming Duriel to obtain your Uber items in Diablo 4 Season 3. However, it's not advisable to begin farming Duriel until you've secured all other necessary gear and resources.