The new Endgame Bosses are finally here in Diablo 4 Season 2. With the addition of these new endgame bosses, we have a new and more intentional way to farm Unique Items, including Uber Uniques.

In this guide, we're going over how to unlock Grigoire The Galvanic Saint, Varshan, Lord Zir, and the Ice Beast. I'll also include some boss mechanics to look out for.

Unlock Grigoire

First up, we have Grigoire, The Galvanic Saint. This endgame boss is unlocked by completing Helltides.

Firstly, you'll need to collect a whopping 300 Aberrant Cinders. Trying to collect this many cinders and then dying is really punishing.

After collecting 300 cinders, you'll need to locate a hidden chest within the Helltide area.

If you hover over the chest on the mini map, it'll be called the Tortured Gift of Infernal Steel. Touching the chest will unlock the mini boss attached to it. Don't worry, they're about as easy as a dungeon boss.

After killing the mini boss, go back to the chest to claim the rewards. Every chest I've opened yielded 3 Living Steel.

If you read the help text on the item in the consumables tab, it'll mention that you'll need a total of 2 to fight Grigoire in World Tier III and a total of 5 in World Tier IV.

After you've collected the 5 Living Steel, head to Hall of the Penitent in Dry Steppes.

When you get to the Altar, use your 5 living steel to summon Grigoire.

Grigoire's boss mechanics revolve around his lightning based attacks. You will need to avoid the lightning grid around the stage. After his 3rd life marker, you'll need to dodge his square patterns on the stage.

Be sure to pick up the Shard of Agony after defeating Grigoire, as we will need this to pop Duriel later.

Defeating Grigoire has the potential to drop these unique items.

Unlock Varshan

Next up, we're doing Varshan.

Varshan's special token items come from completing Whispers. I really recommend doing Legion Events any time they're available as they can give both Grim Favors and the token items required for Lord Zir.

Opening a Whisper Cache will drop body parts for Varshan. With each Cache, you'll potentially receive a Trembling Hand, Gurgling Head, Malignant Heart or a Broken Femur. You will need 1 of each in order to summon Varshan.

If you get unlucky and receive too much of one item, you can exchange these extra parts for Malignant Body Caches at the Alchemist. Each Malignant Body Cache will cost Rare Salvage Materials and Diablo 4 Gold to buy.

It will also not guarantee any specific missing body part when opened. When you have at least one of each body part, right next to the Tree of Whispers is the entrance to Varshan.

Varshan's boss mechanics are mostly cleaves and small projectiles. After half health, watch out for his cone and reverse cone telegraphs.

Defeating Varshan will drop a Mucus Slick Egg. It's one of the two Diablo 4 Items needed to pop Duriel later.

Here is Varshan's unique drop table.

Unlock Lord Zir

Number 3 on the list is Lord Zir.

To pop Lord Zir, you'll first need to collect Exquisite Blood. This is done by either completing Legion Events or World Bosses. I've observed so far that Legion Events will drop one, and World Bosses will drop three.

Collecting Lord Zir's token item is a straightforward process, unlike the previous two. Once you have collected 9 of these tokens, you're ready to head to The Darkened Way in Fractured Peaks. Just inside this area, you'll see another dungeon entrance called The Ancient Seat.

Lord Zir only has one notable attack with a long charge animation. Other than that, just stay off the red circles and you'll be good.

Here's the unique drop table for Lord Zir.

Unlock Ice Beast

And last up, we have the Ice Beast. You'll need a total of 9 token items called Distilled Fear.

On the token item itself, it says you'll need to complete Nightmare Dungeons with a tier of 30 of higher.

It's possible that farming these at a higher tier Nightmare Dungeon might actually give you a better chance of dropping a token. This took me somewhere between 12 to 14 Nightmare Dungeons to collect all 9 tokens.

Once you're ready, craft the sigil called Glacial Fissure at the Occultist and consume the sigil and teleport yourself to the entrance, exactly like a Nightmare Dungeon.

Inside the dungeon, I was surprised by the amount of mobs between the entrance and the unlock Ice Beast boss. You could use this opportunity to get some good experience.

Unlike the previous 3 bosses, the Ice Beast was tough. His health pool was similar to the others, but his boss mechanics were very unforgiving if you made a mistake.

There are 2 mechanics I recommend looking out for:

He does a circle area affect with cones around the outside multiple times. If you get hit by one of these, it's hard to make it out with only using the evade button.

The other mechanic is when the outside becomes off limits and multiple line attacks are telegraphed.

Ideally, you'll dodge to the safe area or you'll get knocked back into the outer area that inflicts damage over time. Unfortunately, even after 4 tries, I wasn't able to beat the Ice Beast. Maybe I'll have better luck next time.

Here's the unique item drop table for the Ice Beast.

Unlock Uber Duriel

To face off against Duriel, you'll need to collect 2 Mucus Eggs from Varshan and 2 Shards of Agony from Grigoire.

Duriel's spawn location is in the Southern part of Kehjistan in a dungeon called the Gaping Crevasse.

I'm expecting Duriel King of Maggots to be a similar difficulty to Uber Lilith. Hopefully, his boss mechanics aren't too difficult.

Also Read: A Potential Top-Tier Build For The Bone Spear Necromancer In Diablo 4 Season 4 Revealed

As we all know, there will be 5 bosses in Diablo 4 Season of Blood, and they will have their own drop tables with specific unique items on them. We have Varshan returning from Season 1, the ultimate boss of Season 2, Lord Zir, and 3 new bosses: Galvanic Saint, Beast in the Ice, and Duriel, King of Maggots.

Summoning Materials

We will summon these bosses using specific materials. For example, Galvanic Saint will require Helltide materials. Lord Zir will require World Boss and Legion event materials. Varshan will need Tree of Whispers bounty material.

Finally, Duriel will need materials from other World Tier 4 bosses. His chance of dropping Uber Uniques also increases! It is said that Uber Uniques will be dropped when the new item strength reaches 920. Diablo 4 items required to summon these bosses will be tradable between players.

This Diablo 4 guide aims to dissect that information, providing an in-depth look at the loot drop system and what players can expect from each endgame boss.

Endgame Bosses

Reinforcements from the darkest depths of Burning Hell take over Sanctuary, ushering in a new era of death and wanton destruction. This batch of ultra-difficult endgame bosses are not for the faint of heart, but the chance to earn unique and cosmetic items awaits those who muster the courage to take on them.

Each boss has a variety of unique items that can be dropped, some of which are unique to that boss. The same goes for the special items they may drop. You can earn tons of Diablo 4 Gold by selling these unique items.

Starting in World Tier 3, you can test yourself on killing these ugly bosses in Eternal or Seasonal Realms. In World Tier 4, more intense encounters await you. Here are the requirements for encountering them and the rewards you may receive.

Grigoire, The Galvanic Saint (World Tier 3 & 4): You must collect enough Living Steel from Tortured Offering in Helltide. In addition to unique items that can only be dropped from Grigoire, you also have a chance to obtain Demonbinder Mount Armor Cosmetic.

Echo of Varshan (World Tier 3 & 4): Defeating Grotesque Debtors in Whispers of the Dead gives you a chance to get a part of Varshan’s body. Once you have enough parts, including Malignant Heart, you can summon Varshan. In addition to unique items that can only be dropped from Varshan, this boss also has a chance to drop Flesh-Weld Rod Trophy.

Beast in the Ice (World Tier 4): Collect Distilled Fear when completing Nightmare Dungeon at level 30 or higher. When you have collected enough, visit Occultist and craft Glacial Fissure Nightmare Sigil. Then activate it and you can fight Beast in the Ice. In addition to the unique items unique to it, Skull Torch and Fell Steed Mount Trophies may also drop from this boss.

Dark Master (World Tier 4): By completing World Boss or Legion event in World Tier 4, you will earn Exquisite Blood. Once you have enough, you can summon Dark Master. In addition to its unique item, Diadem of the Ancient Helm Cosmetic may also drop from this boss.

Echo of Duriel (World Tier 4): Defeat Galvanic Saint and Varshan in World Tier 4 to collect Mucus-Slick Eggs and Shards of Agony. Once you have enough resources, you can summon Lord of Pain, Duriel!

Among the bosses, Duriel is the only one with a chance of dropping Uber Unique items. They can also drop Smoldering Brimstone Mount from this boss.

Extra Tips

Every time you want to fight a boss, you’ll need to meet its summoning conditions, so keep any extra summoning materials you might have picked up along the way.

Meanwhile, preparing for these bosses requires a layered approach. Collect materials for the first set of bosses, starting with Whispers and Helltide. Once defeated, these bosses provide materials for the next group.

For fans of Diablo 1, the process may be similar to Uber Tristram event. Players need to collect Mucus-Slick Eggs from the primary boss to access Duriel. We should note that failing against Duriel means you will lose the ingredients to summon him.

While the opportunity to target the farm’s powerful unique creatures is exciting, there are concerns about the difficulty level. Uber Lilith’s current situation sets a precedent for an almost impossible challenge. We want Duriel to be challenging. He has to be tough, but not so strong that he’s inaccessible to most players.